Lrp1: New host factor for Rift Valley fever virus infection

A major study of ours was just published in Cell, with a fabulous Leading Edge review written about the study. We had no idea that Cell was soliciting a review, so this was a complete surprise!

You can read my synopsis of our work and how it came about in my twitter thread here.

This was such an interesting journey from meeting Dr. Gaya Amarasinghe at NSV2018 to publication! Lots of individuals contributed over the years at several institutions and I’m super proud of this work. I’m also glad we can talk about it! The Lrp1 story has turned into a major effort in our lab and has cross-cutting implications for all of our projects.

Gaya and Amy at the Negative Strand Virus (NSV) Conference in 2018. This was the genesis of the Lrp1 project!

Gaya and Amy at the Negative Strand Virus (NSV) Conference in 2018. This was the genesis of the Lrp1 project!

Ganaie, S.S., M.M. Schwarz, C.M. McMillen, D. Price, A. Feng, J.R. Albe, W. Wang, S. Miersch, A. Ovredahl, A.R. Cole, M.F. Sentmanat, N. Mishra, D.A. Boyles, Z.T. Koenig, M.R. Kujawa, M.A. Demers, R.M. Hoehl, A. Moyle, N. Wagner, S.H. Stubbs, L. Cardarelli, J. Teyra, A.K. McElroy, M.L. Gross, S.P.J. Whelan, J. Doench, X. Cui, T.J. Brett, S.S. Sidhu, H.W. Virgin, T. Egawa, D.W. Leung, G.K. Amarasinghe, and A.L. Hartman. Lrp1 is a host entry factor for Rift Valley Fever Virus. Cell. Published online 23 September 2021.